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生物資訊教學
生物資訊是一門整合生命科學與電腦科學的跨領域研究。此Wiki由【計算生物學】與【生物資訊演算法】之修課學生,國立中正大學生物資訊實驗室同學,與指導老師黃耀廷博士所共同編寫。生物資訊之背景知識,涵蓋部份生物、遺傳、統計、與演算法之背景知識,可分以下子課題介紹:
Assembly Tool: 沒有參考基因體(Reference Genome)的物種(例如,鴿子、蓮霧),定序完必須把破碎的序列重組出一條參考基因體。-
Assembly Tools:
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Overlap-graph assemblers: MIRA、AMOS package
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Scaffolder: SOAPdenovo, SSPACE, Bambus, IMAGE2.
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Alignment Tool: 已經有參考基因體的物種(例如,人類、稻米),定序完可以直接把序列對回去(Align)參考基因體。
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Variation Discovery Tool: 把序列對回去參考基因體後,可以進一步分析該個體是否有突變。
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Small indel discovery tool: SAMTool for Indels、AB Small Indel Tool
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Large Indel discovery tool:BreakDancer、AB Large Indel Tool
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Copy Number estimation tool:CNVseq
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Structural Variant discovery tool:BreakDancer、GASV
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Chip Seq: analyze protein interactions with DNA, which is often used to identify transcription factor binding sites.
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Exome Seq: target sequence of exons in the genome.
God, seven years did a lot to their bodies.Simon’s yoguner than Obama (like 18 or 20), yet he’s kicking ass getting other people to kick it for him. Hell, with Gurren Lagann, he could end the War in Iraq find Bin Laden before a month passed.Rossiu really needs to can it. He needs to be more like Kitan careless.Nia looks cute. Shocking how she really is a *SPOILER ALERT*, though.