http://bib.oxfordjournals.org/content/13/4/495.full
Key Points
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Vast amounts of variation data from genome sequencing studies need to be analyzed to understand its association with various phenotypes.
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Well-curated databases, reliable tools for gene prioritization and accurate methods for predicting the impact of variants will be essential for the interpretation of personal genomes.
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Standard and unified protocols for testing the functional impact of genetic variations are critical for their accurate annotation.
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Experimental studies and computational models describing the gene/protein interaction networks and aiming at capturing the fullcomplexity of the human genome will be key to leveraging personal genomic data for the precise diagnosis and effectivetreatment of disease.
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