Summary: HSPIR is a concerted database of six major Heat ShockProteins (HSPs) namely Hsp70, Hsp40, Hsp60, Hsp90, Hsp100 and sHsp (small HSP). The HSPs are essential for the survival of all living organisms which protects the conformations of proteins upon exposure to various stress conditions. They are highly conserved group of proteins involved in diverse physiological functions, including de novofolding, disaggregation and protein trafficking. Moreover, their critical role in the control of disease progression made them a prime target of research. Presently, limited information is available on HSPs in reference to their identification and structural classification across genera. To that extent, HSPIR provides manually curated information on sequence, structure, classification, ontology, domain organization, localization and possible biological functions extracted from UniProt, GenBank, PDB and the literature. The database offers interactive search with incorporated tools, which enhances the analysis. HSPIR is a reliable resource for researchers exploring structure, function and evolution of HSPs.
Availability: http://pdslab.biochem.iisc.ernet.in/hspir/
Contact: patrick@biochem.iisc.ernet.in
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